Registered report: tumour vascularization via endothelial differentiation of glioblastoma stem-like cells

注册报告:胶质母细胞瘤干细胞样细胞内皮分化介导的肿瘤血管生成

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作者:Denise Chroscinski ,Darryl Sampey ,Nimet Maherali

Abstract

The Nature in 2010 (Ricci-Vitiani et al., 2010). The experiments that will be replicated are those reported in Figure 4B and Supplementary Figure 10B (Ricci-Vitiani et al., 2010), which demonstrate that glioblastoma stem-like cells can derive into endothelial cells, and can be selectively ablated to reduce tumor progression in vivo, and Supplementary Figures S10C and S10D (Ricci-Vitiani et al., 2010), which demonstrate that fully differentiated glioblastoma cells cannot form functionally relevant endothelium. The Reproducibility Project: Cancer Biology is a collaboration between the eLife.

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