Abstract
BACKGROUND AND OBJECTIVES: Impaired health-related quality of life (HRQoL) and psychological symptoms after melanoma surgery are common, but research often focuses on specific stages, older patients, or clinical trial settings. This study aims to identify sub-groups of surgically treated melanoma patients in a real-world setting by examining associations between clinical and sociodemographic factors and psychosocial well-being. METHODS: Patients attending follow-up at the Department of Plastic Surgery, Herlev and Gentofte Hospital, were invited to this cross-sectional, questionnaire-based study. Eight validated patient-reported outcome measures assessed HRQoL, psychological symptoms, work ability, and patient activation. A study-specific questionnaire evaluated satisfaction and follow-up experiences. RESULTS: 251/489 patients (51%) completed the questionnaires. Over one-third had high fear of cancer recurrence, and one in five reported high distress. Stage IV patients had the highest psychological symptom burden and lowest HRQoL, work ability, and patient activation. Younger age was linked to more psychological symptoms, and female gender to lower work ability. Stage IV disease and low income were associated with lower patient activation. About 20% felt more anxious before follow-ups. CONCLUSION: Findings highlight the need for follow-up that supports psychosocial well-being after melanoma surgery, particularly in younger patients and those with advanced melanoma.