Abstract
OBJECTIVES: This study aimed to evaluate if there is a role for hypoglossal nerve stimulation outside the original Stimulation Therapy for Apnea Reduction (STAR) trial criteria. METHODS: This review was conducted using PubMed, Embase and Cochrane Library databases. RESULTS: Hypoglossal nerve stimulation led to improved outcomes in individuals who fell outside the STAR trial criteria for apnoea-hypopnoea index and body mass index. However, this improvement did not extend to patients with complete concentric palatal collapse or those with a significant central apnoea component. CONCLUSION: Hypoglossal nerve stimulation can be effective in patients outside the original STAR trial criteria for certain parameters. Further research is needed to refine patient selection criteria for optimal outcomes.