Impact of hepatitis B virus surface protein mutations on the diagnosis of occult hepatitis B virus infection

乙肝病毒表面蛋白突变对隐匿性乙肝病毒感染诊断的影响

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作者:Mira El Chaar, Daniel Candotti, R Anthony Crowther, Jean Pierre Allain

Conclusion

Escape mutation is a mechanism associated with OBI, which also leads to decreased reactivity in HBsAg detection assays. Performance of commercial assays would be improved by the incorporation of OBI mutants in reagent development.

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