Abstract
BACKGROUND: Integrating artificial intelligence (AI) prospected in the practical clinical management of polycystic ovary syndrome (PCOS) promised significant improvement in efficiency, interpretability, and generalizability. PURPOSE: To delineate a comprehensive inventory of AI-driven interventions pertinent to PCOS across diverse clinical contexts. EVIDENCE REVIEWS: AI-based analytics profoundly transformed the management of PCOS, particularly in the domains of prediction, diagnosis, classification, and screening of potential complications. RESULTS: Our analysis traced the principal applications of AI in PCOS management, focusing on prediction, diagnosis, classification, and screening. Furthermore, this study ventures into the potential of amalgamating and augmenting existing digital health technologies to forge an AI-augmented digital healthcare ecosystem encompassing the prevention and holistic management of PCOS. We also discuss strategic avenues that may facilitate the clinical translation of these innovative systems. CONCLUSION: This systematic review consolidated the latest advancements in AI-driven PCOS management encompassing prediction, diagnosis, classification, and screening of potential complications, developing a digital healthcare framework tailored to the practical clinical management of PCOS.