Association of the nutritional risk index recorded prior to allogeneic hematopoietic cell transplantation with the clinical prognosis in children

异基因造血干细胞移植前记录的营养风险指数与儿童临床预后的相关性

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Abstract

INTRODUCTION: The nutritional risk index (NRI), calculated using serum albumin levels and body weight ratio is a known prognostic factor in adult hematopoietic cell transplantation (HCT). However, its usefulness in pediatric HCT settings remains unclear. METHODS: In a retrospective study, we examined pre-transplant NRI impact on outcomes in 82 pediatric patients undergoing allogeneic HCT. RESULTS: The 2-year non-relapse mortality (NRM) rate was 7.94% (95% confidence interval [CI], 3.05%-19.8%) and 30.8% (95% CI, 16.7%-52.2%) in the high and low NRI groups, respectively (p = 0.0037). CONCLUSION: We found that poor nutritional status prior to pediatric HCT led to a worse prognosis, including increased NRM.

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