Abstract
Sickle cell disease (SCD) is associated with cardiac remodeling, particularly left atrial dilatation, which may predict adverse cardiovascular outcomes. This study assessed cardiac abnormalities using echocardiography in 59 adult SCD patients and explored biomarkers predictive of left atrial remodeling. Left atrial dilatation was found in 61% of patients and significantly associated with hemoglobin, hemoglobin S, HDL-C, and the atherogenic index of plasma. An algorithm combining hemoglobin ≤ 9.7 g/dL and HDL-C ≤ 50 mg/dL showed high-diagnostic performance. These findings support biomarker-based screening as a useful tool in resource-limited settings for early detection of cardiac complications in SCD. Trial Registration: ClinicalTrials.gov identifier: NCT05376046.