Abstract
Primary pulmonary synovial sarcoma (PPSS) is a rare and challenging malignancy in terms of diagnosis and treatment. We narrated a case of PPSS treated innovatively by integrating photodynamic therapy (PDT) and localized radiation, overcoming diagnostic and treatment challenges associated with PPSS. The combination significantly improved clinical symptoms and patient survival. The case sheds light on a promising therapeutic strategy, augmenting the treatment discourse for PPSS and potentially guiding future clinical practices in managing this rare malignancy.