Abstract
OBJECTIVE: Hepatic cells face oxidative stress-induced damage, but plant antioxidants may offer protection. This study aimed to assess Elaeagnus angustifolia L. fruit extract's potential in shielding rat livers from CCl(4) damage. MATERIALS AND METHODS: 30 Male Wistar rats were randomly divided into five groups: normal control (received distilled water), E. angustifolia hydroalcoholic extract control, CCl(4) control, E. angustifolia extract pretreatment (600 mg/kg), and silymarin pretreatment (100 mg/kg). After 14 days of oral administration of extracts, CCl(4) was injected intraperitoneally. The samples were collected 48 hr later. Histological and biochemical analyses were then carried out. RESULTS: CCl(4) injection caused significant (p<0.001) changes in liver serum enzymes, lipid profile, bilirubin, total protein, serum albumin, antioxidant enzymes, malondialdehyde, Inflammatory cytokines, and liver tissue morphology. E . angustifolia extract pre-treatment significantly (p<0.05) returned changes to the normal state. CONCLUSION: This study's findings revealed that E. angustifolia extract pretreatment could reduce liver injury caused by CCl(4) in rats.