Abstract
Myelin's role in processing speed is pivotal, as it facilitates efficient neural conduction. Its decline could significantly affect cognitive efficiency during ageing. In this work, myelin content was quantified using our advanced MRI method of myelin water fraction mapping. We examined the relationship between myelin water fraction at the time of MRI and retrospective longitudinal change in processing speed among 121 cognitively unimpaired participants, aged 22-94 years, from the Baltimore Longitudinal Study of Aging and the Genetic and Epigenetic Signatures of Translational Aging Laboratory Testing (a mean follow-up duration of 4.3 ± 6.3 years) using linear mixed-effects models, adjusting for demographics. We found that higher myelin water fraction values correlated with longitudinally better-maintained processing speed, with particularly significant associations in several white matter regions. Detailed voxel-wise analysis provided further insight into the specific white matter tracts involved. This research underscores the essential role of myelin in preserving processing speed and highlights its potential as a sensitive biomarker for interventions targeting age-related cognitive decline, thereby offering a foundation for preventative strategies in neurological health.