Abstract
Prevention offers the greatest public health potential and the most cost-effective long-term cancer control strategy. Authoritative, clear, evidence-based, and region-specific recommendations to actively contribute to cancer prevention are extremely valuable for the public, health professionals, advocates, and policymakers worldwide. The World Code Against Cancer Framework offers a two-level hierarchy mechanism to systematically review and synthesize the latest scientific insights, while assessing the epidemiological, socioeconomic, cultural conditions, and health systems context of a given region of the world, to inform decision-making at the individual and system levels, implemented through Regional Codes Against Cancer. In this manuscript, we describe the rigorous methodology established by the International Agency for Research on Cancer, consisting of a step-by-step decision-making algorithm to develop region-specific Codes Against Cancer. These comprehensive evidence-based tools on cancer prevention aim to transfer the latest evidence from etiological research and preventive interventions into actionable information for the population and for policymakers.