Abstract
Amebiasis, caused by Entamoeba histolytica, is an intestinal disease that can lead to severe complications such as ulcers and abscesses. While the intestine is most commonly affected, extraintestinal involvement is also possible. However, mediastinal amebiasis remains rare. This case report details a patient with amebiasis who developed an amebic mediastinal abscess, which subsequently ruptured into the pleural cavity, resulting in bilateral empyema and a pseudoaneurysm of the right subclavian artery. Treatment was promptly initiated with metronidazole, alongside closed pleural drainage. Additionally, endovascular stent placement was performed to address the right subclavian artery pseudoaneurysm. The patient was discharged in good health on the 37th postoperative day. The treatment approach described offers valuable clinical insights for frontline healthcare providers.