Abstract
We describe clinical characteristics and deep immunophenotypes in two patients with myelin-oligodendrocyte-glycoprotein (MOG)-antibody-associated-disease after COVID-19. The para-COVID case was a 74-year-old man who developed optic neuritis two days after COVID-19. Immunological assays revealed reduced absolute CD8(+) T- and B-cell counts with increased frequency of NK cells. Post-COVID case was a 63-year-old man with optic neuritis six months after COVID-19, a frequency of CD8(+) T-cells was elevated with a relatively low fraction of naïve and a high fraction of effector memory CD8(+) T-cells. There was increased frequency of CD8(+)CD38(+)HLA-DR(+) T-cells in the para-COVID case; interestingly, CD4(+)CD38(+)HLA-DR(+) T cell frequency was increased in the post-COVID case. Both had increased SARS-CoV-2-specific and MOG-specific T-cell responses.