Abstract
BACKGROUND: This study will analyse the changes in serum nutrient protein, a proinflammatory cytokine, and immunoglobulins before and after enteral nutrition support (ENS) in patients with intracerebral haemorrhage (ICH), which will serve as a reference for future clinics when performing ENS. METHODS: This retrospective observational study included 160 patients with ICH (76 in the intermittent group and 84 in the continuous group), and changes in indicators before and after EN intervention were retrospectively analysed in both groups, including serum nutrient protein (albumin ALB, transferrin TRF, prealbumin PAB), proinflammatory cytokine (IL-1 b, IL-6, TNF-a), immunoglobulins (IgA, IgG, IgM) and gastrointestinal tolerance. RESULTS: There was no difference in adverse reactions between the two groups during ENS (P>0.05). After ENS, ALB, TRF PAB, IgA, IgG, and IgM were significantly increased in both groups, while IL-1 b, IL-6, and TNF-a were decreased (P<0.05). After ENS, there was no difference in serum nutrient protein between the two groups (P>0.05). Still, proinflammatory cytokines were lower in the intermittent group than in the continuous group, while immunoglobulins were higher than in the intermittent group (P<0.05). CONCLUSIONS: ENS exerts neuroprotection through the "intestinal barrier repair-immune remodeling-inflammation inhibition axis".