DNA methylation markers for breast cancer prognosis: Unmasking the immune component

DNA甲基化标志物在乳腺癌预后中的作用:揭示免疫成分

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Abstract

Currently, most of the prognostic and predictive gene expression signatures emerging for breast cancer concern the tumor component. In Dedeurwaerder et al. we show that DNA methylation profiling of breast tumors is a particularly sensitive means of capturing features of the immune component of breast tumors. Most importantly, correlation is observed between T-cell marker genes and breast cancer clinical outcome.

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