Abstract
INTRODUCTION: We report two cases of ectopic prostate tissue exhibiting fluorescence during photodynamic diagnosis using 5-aminolevulinic acid. CASE PRESENTATION: The first case involved a 57-year-old man with a 9-mm papillary tumor on the right side of the bladder neck. The second case involved a 75-year-old man with a history of left renal pelvic cancer who presented with a 2-mm papillary tumor in the bladder trigone. In both cases, the tumors fluoresced red under blue light during photodynamic diagnosis-assisted transurethral resection. Histopathological examination revealed ectopic prostate tissue in both cases. No recurrence was observed, and a slight decrease in serum prostate-specific antigen levels was noted at 12 and 5 months of follow-up in cases 1 and 2, respectively. CONCLUSION: Ectopic prostate tissue in the bladder is a rare benign tumor that may exhibit false-positive fluorescence during photodynamic diagnosis, making it difficult to distinguish from bladder cancer even with this technique.