Effect of controlled surface roughness and biomimetic coating on titanium implants adhesion to the bone: An experiment animal study

控制表面粗糙度和仿生涂层对钛种植体与骨黏附的影响:动物实验研究

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作者:Mohamed Ahmed Alkhodary

Conclusion

Two novel surface treatments were used: laser micro-grooving and tri peptide RGD coating, both of which had different effects on the dental implant interface. Laser grooving improved peri-implant bone healing, whereas RGD coating facilitated earlier bone-implant adhesion and better mineralization.

Methods

In this study, the test groups consisted of 1.5-mm diameter, 5-mm long laser-grooved and laser-grooved/RGD coated titanium alloy (Ti-6Al-4 V) rods, and the control group included plain titanium alloy (Ti-6Al-4 V) rods. These rods were implanted in the mandibles of New Zealand white rabbits for 2, 4, and 6 weeks. After sacrifice, the test and control specimens were retrieved for mechanical pullout testing. The DMA 7-e was used to pull the titanium rods out of the bone, the probe position was plotted versus time graph to monitor the test progression, and the static modulus versus time graph was viewed; such graphs was then transformed into tables. The

Results

The laser-grooved/RGD coated rods had significantly higher pull-out strength than the laser-grooved and control rods. Additionally, the laser-grooved rods had significantly higher pull-out strength than control rods.

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