Abstract
BACKGROUND: Previous studies have suggested that end-tidal CO(2) (ET-CO(2)) may be inaccurate during one-lung ventilation (OLV). This study was performed to compare the accuracy of the noninvasive monitoring of PCO(2) using transcutaneous CO(2) (TC-CO(2)) with ET-CO(2) in patients undergoing video-assisted thoracoscopic surgery (VATS) during OLV. MATERIALS AND METHODS: In adult patients undergoing thoracoscopic surgical procedures, PCO(2) was simultaneously measured with TC-CO(2) and ET-CO(2) devices and compared with PaCO(2). RESULTS: The cohort for the study included 15 patients ranging in age from 19 to 71 years and in weight from 76 to 126 kg. During TLV, the difference between the TC-CO(2) and the PaCO(2) was 3.0 +/- 1.8 mmHg and the difference between the ET-CO(2) and PaCO(2) was 6.2 +/- 4.7 mmHg (P=0.02). Linear regression analysis of TC-CO2 vs. PaCO(2) resulted in an r(2) = 0.6280 and a slope = 0.7650 +/- 0.1428, while linear regression analysis of ET-CO(2)vs. PaCO(2) resulted in an r(2) = 0.05528 and a slope = 0.1986 +/- 0.1883. During OLV, the difference between the TC-CO(2) and PaCO(2) was 3.5 +/- 1.7 mmHg and the ET-CO(2) to PaCO(2) difference was 9.6 +/- 3.6 mmHg (P=0.03 vs. ET-CO(2) to PaCO(2) difference during TLV; and P<0.0001 vs. TC-CO(2) to PaCO(2) difference during OLV). In 13 of the 15 patients, the TC-CO(2) value was closer to the actual PaCO(2) than the ET-CO(2) value (P =0.0001). Linear regression analysis of TC-CO(2)vs. PaCO(2) resulted in an r(2) = 0.7827 and a slope = 0.8142 +/- 0.0.07965, while linear regression analysis of ET-CO(2)vs. PaCO(2) resulted in an r(2) = 0.2989 and a slope = 0.3026 +/- 0.08605. CONCLUSIONS: During OLV, TC-CO(2) monitoring provides a better estimate of PaCO(2) than ET-CO2 in patients undergoing VATS.