Measures of biomarker dependence using a copula-based multivariate epsilon-skew-normal family of distributions

使用基于 copula 的多变量 epsilon-skew-normal 分布族来衡量生物标志物依赖性

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Abstract

In this note we develop a new multivariate copula model based on epsilon-skew-normal marginal densities for the purpose of examining biomarker dependency structures. We illustrate the flexibility and utility of this model via a variety of graphical tools and a data analysis example pertaining to salivary biomarker. The multivariate normal model is a sub-model of the multivariate epsilon-skew-normal distribution.

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