Construction, Expression, and Evaluation of the Naturally Acquired Humoral Immune Response against Plasmodium vivax RMC-1, a Multistage Chimeric Protein

针对间日疟原虫 RMC-1（一种多级嵌合蛋白）的自然获得性体液免疫反应的构建、表达和评估

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作者：Ada da Silva Matos, Isabela Ferreira Soares, Barbara de Oliveira Baptista, Hugo Amorim Dos Santos de Souza, Lana Bitencourt Chaves, Daiana de Souza Perce-da-Silva, Evelyn Kety Pratt Riccio, Letusa Albrecht, Paulo Renato Rivas Totino, Rodrigo Nunes Rodrigues-da-Silva, Cláudio Tadeu Daniel-Ribeiro, Li

期刊：

International Journal of Molecular Sciences

影响因子：

0.700

时间：

2023

起止号：

2023 Jul 18;24(14):11571.

doi：

10.3390/ijms241411571

研究方向：

免疫

Conclusions

The study demonstrates that PvRMC-1 was successfully expressed and targeted by natural antibodies, providing important insights into the construction of a multistage chimeric recombinant protein and the use of naturally acquired antibodies to validate the construction.

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