Abstract
Cancer is a major global health challenge, accounting for nearly one in six deaths worldwide. Early diagnosis significantly improves survival rates and patient outcomes, yet in resource-limited settings, the scarcity of medical resources often leads to late-stage diagnosis. Integrating artificial intelligence (AI) with smartphone-based imaging systems offers a promising solution by providing portable, cost-effective, and widely accessible tools for early cancer detection. This paper introduces advanced smartphone-based imaging systems that utilize various imaging modalities for in vivo detection of different cancer types and highlights the advancements of AI for in vivo cancer detection in smartphone-based imaging. However, these compact smartphone systems face challenges like low imaging quality and restricted computing power. The use of advanced AI algorithms to address the optical and computational limitations of smartphone-based imaging systems provides promising solutions. AI-based cancer detection also faces challenges. Transparency and reliability are critical factors in gaining the trust and acceptance of AI algorithms for clinical application, explainable and uncertainty-aware AI breaks the black box and will shape the future AI development in early cancer detection. The challenges and solutions for improving AI accuracy, transparency, and reliability are general issues in AI applications, the AI technologies, limitations, and potentials discussed in this paper are applicable to a wide range of biomedical imaging diagnostics beyond smartphones or cancer-specific applications. Smartphone-based multimodal imaging systems and deep learning algorithms for multimodal data analysis are also growing trends, as this approach can provide comprehensive information about the tissue being examined. Future opportunities and perspectives of AI-integrated smartphone imaging systems will be to make cutting-edge diagnostic tools more affordable and accessible, ultimately enabling early cancer detection for a broader population.