Abstract
Over the past few years, hydrogen sulfide (H(2)S) has been shown to exert several biological functions in mammalian. The endogenous production of H(2)S is mainly mediated by cystathione β-synthase, cystathione γ-lyase and 3-mercaptopyruvate sulfur transferase. These enzymes are broadly expressed in liver tissue and regulates liver function by working on a variety of molecular targets. As an important regulator of liver function, H(2)S is critically involved in the pathogenesis of various liver diseases, such as non-alcoholic steatohepatitis and liver cancer. Targeting H(2)S-generating enzymes may be a therapeutic strategy for controlling liver diseases. This review described the function of H(2)S in liver disease and summarized recent characterized role of H(2)S in several cellular process of the liver. [BMB Reports 2022; 55(10): 481-487].