Effectiveness of a low-fructose and/or low-sucrose diet in decreasing insulin resistance (DISFRUTE study): study protocol for a randomized controlled trial

低果糖和/或低蔗糖饮食对降低胰岛素抵抗的有效性(DISFRUTE 研究):随机对照试验的研究方案

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作者:Santiago Domínguez Coello, Lourdes Carrillo Fernández, Jesús Gobierno Hernández, Manuel Méndez Abad, Carlos Borges Álamo, José Antonio García Dopico, Armando Aguirre Jaime, Antonio Cabrera de León; DISFRUTE Group

Background

Research published to date on the relationship between insulin resistance (IR) and fructose consumption is scarce, has used different

Discussion

If the dietary intervention being tested, i.e., a diet low in fructose/sucrose, is able to reduce IR, the results - if translated into regular clinical practice - could provide a hitherto unavailable tool to prevent type-2 diabetes mellitus.

Trial registration

ISRCTN, ID: ISRCTN41579277 . Registered retrospectively on 15 November 2016.

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