Abstract
OBJECTIVES: Brief cognitive tests are recommended in clinical services outside of specialized memory clinics as case-finding tools to reduce the diagnostic gap of dementia. Although the Montreal Cognitive Assessment (MoCA) is among the most widely used brief tests in specialized memory clinics, its length precludes routine use in nonspecialty clinics. This study investigated whether a small subset of MoCA would suffice to match the performance of the full MoCA in detecting dementia and, hence, be useful in nonspecialty clinics. DESIGN: Cross-sectional test research. SETTING: Alzheimer's Disease Centers across the United States. PARTICIPANTS: Participants age ≥65 years (n = 8773). MEASURES: Participants completed MoCA and were evaluated for dementia. The study sample was split into 2: the derivation sample (n = 4386) was used to develop a short variant of MoCA that best distinguish dementia (using the best-subset-approach with 10-fold cross-validation), while the validation sample (n = 4387) verified its actual performance using area under the receiver operating characteristic-curve (AUC). RESULTS: A 4-item cognitive test was identified, comprising Clock-drawing, Tap-at-letter-A, Orientation, and Delayed-recall. It demonstrated excellent performance in distinguishing dementia from nondementia (AUC 94.2%) and was comparable to that of MoCA (AUC 93.8%), even across education subgroups. It explained 85.9% of the variability in MoCA and had scores that could be mapped to MoCA with reasonable precision. At the optimal cut-off score of <10, it demonstrated 87.9% sensitivity and 87.6% specificity in detecting dementia. CONCLUSIONS AND IMPLICATIONS: Using rigorous methods, this study developed a brief cognitive test that is free of charge, takes <5 minutes to complete, covers the key cognitive domains, and has standardized instructions to allow its administration even by nonphysicians. This brief test is well suited as a case-finding tool in nonspecialty clinics (such as in primary care and geriatric clinics) and may improve care-integration with specialized memory clinics that utilize MoCA.