Abstract
Severe acute respiratory syndrome coronavirus 2, the virus that causes coronavirus disease (COVID-19), has undergone numerous mutations since its initial identification, leading to challenges in controlling the pandemic. Till date, several variants of concern have been identified. However, currently, the Delta variant (B.1.617.2) is the most dreaded one owing to its enhanced transmissibility and increased virulence. In addition, this variant can potentially facilitate fusion of the spike protein to cells or inhibit antibodies from binding to it. In this commentary, we have simplified the complexity of the nomenclature of variants related to COVID-19, concentrating on the Delta variant including its transmissibility, response to vaccines, and prevention.