Abstract
MXene, as an emerging two-dimensional (2D) material with ultrathin structure and fascinating physiochemical properties, has been widely explored in broad applications. Versatile functions of MXenes are continuously explored. This work presents distinctive feature of MXene-Ti(3)C(2)T (x) nanosheets for free-radical (FRs) scavenging that never reported before. We demonstrated the mechanism and equation in regard to the reaction between Ti(3)C(2)T (x) and H(2)O(2), which was applied to design colorimetric H(2)O(2) strip assay with good performance. The good FRs scavenging capability of Ti(3)C(2)T (x) , including a series of reactive oxygen species (ROS) and reactive nitrogen species (RNS), was systemically confirmed. The antioxidation capability of Ti(3)C(2)T (x) for protecting cells from oxidative damage was demonstrated using the oxidative damage model of alpha mouse liver 12 (AML-12) cells. This original work provides huge opportunities for MXenes in FR-related biomedical applications. ELECTRONIC SUPPLEMENTARY MATERIAL: Supplementary material (further details of the experimental procedures, investigation of the reaction between Ti(3)C(2)T (x) and other oxidants, the characterization of endocytosis of cells for Ti(3)C(2)T (x) , and the comparison of different antioxidants for scavenging free radicals) is available in the online version of this article at 10.1007/s12274-021-3751-y.