Impact of MCT1 Haploinsufficiency on the Mouse Retina

MCT1单倍体不足对小鼠视网膜的影响

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Abstract

The monocarboxylate transporter 1 (MCT1) is highly expressed in the outer retina, suggesting that it plays a critical role in photoreceptors. We examined MCT1 (+/-) heterozygotes, which express half of the normal complement of MCT1. The MCT1 (+/-) retina developed normally and retained normal function, indicating that MCT1 is expressed at sufficient levels to support outer retinal metabolism.

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