Abstract
Neurons in the vertebrate nervous system acquire their mature features over an extended period in pre-natal and early post-natal life. The interaction of the organism with its environment (“experience”) has been shown to profoundly influence sensory neuron development. Over the past ~2 decades, it has become increasingly clear that motor system development is also experience-dependent. Glutamate receptors of the N-methyl-D-aspartate (NMDA) subtype have been implicated in both sensory and motor system experience-dependent development. An additional molecular mechanism involves the GluA1 subunit of the 2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-yl)propanoic acid (AMPA) subtype glutamate receptors. GluA1-dependent development operates in an NMDA-R independent manner and uses a distinct set of signaling molecules. The synapse associated protein of 97 kDa molecular weight (SAP97) is key. A deeper understanding of how experiences guides motor system development may lead to new ways to improve function after central nervous system insult.