Abstract
The 2025 Asia Pacific Congress on Public Health, held in Boao, China, in November 2025, released a transnational consensus and jointly issued the Boao Initiative by Chinese Preventive Medicine Association, World Federation of Public Health Associations, and other six associations from the Asia Pacific region. Centered on the core themes of equity, resilience, and innovation, the Initiative proposes a "Four-in-One" collaborative action plan to address the Asia Pacific region's severe public health challenges. These challenges include fragmented regional public health governance, widening health inequalities, increasing climate-health risks, and structural constraints on digital transformation. To tackle these issues, the "Four-in-One" plan includes four key components: 1) Strengthening regional governance and building joint prevention and control defenses; 2) Advancing health equity and protecting every life; 3) Enhancing health adaptation to climate change and building a resilient barrier; and 4) Leading digital innovation and empowering smart health systems. The initiative underscores the importance of transnational cooperation to build a comprehensive, inclusive, and sustainable public health framework. It reaffirms the Asia Pacific region's commitment to global health governance, advocating for shared responsibility to overcome disparities and foster resilience through innovation. Therefore, the Boao Initiative serves as a strategic roadmap for achieving equitable health outcomes and strengthening regional collaboration in public health.