Abstract
China's human immunodeficiency virus / acquired immune deficiency syndrome (HIV/AIDS) prevention and control efforts have entered a new stage, necessitating the exploration of more effective intervention strategies. HIV pre-exposure prophylaxis (PrEP) is a proven method to prevent HIV infection, but its promotion in China faces challenges such as low public acceptance and inadequate service capacity. To further promote PrEP, the "HIV PrEP Model Exploration Project" was launched, exploring three PrEP service models: PrEP clinics, Digital services and physical testing, and PrEP self-service vending machines. The project achieved certain results, establishing a PrEP service network, training professional staff, and promoting the use of PrEP. In the future, it is necessary to further expand publicity channels, enhance public awareness and acceptance, optimize follow-up management, and promote the popularization of PrEP and HIV/AIDS prevention and control efforts.