Abstract
WHAT IS ALREADY KNOWN ABOUT THIS TOPIC? China is rapidly encountering population aging, yet studies on aging are limited by the traditional aging measure: chronological age, particularly in the field of genomics. Several promising aging measures have been proposed, but they lack comparative evaluation. WHAT IS ADDED BY THIS REPORT? PhenoAge was identified as a measure of aging that demonstrated greater applicability in contemporary populations. Based on this, several novel genetic variants were found to enhance the predictive accuracy of aging. WHAT ARE THE IMPLICATIONS FOR PUBLIC HEALTH PRACTICE? These findings might provide new insights into aging and facilitate the development of a practical screening program based on PhenoAge, which aims to promote healthy aging in China.