Abstract
Colorectal cancer (CRC) ranks third among the most commonly diagnosed cancers in China. Despite proof that screening can decrease CRC incidence and mortality, there are still gaps remaining between CRC screening objectives and reality in China. In this review, we provided an overview of the status of CRC screening in China. First, we summarized the current CRC screening programs and strategies in China. Second, we reviewed the authoritative CRC screening and early detection guidelines in China to orient future evidence-based guideline development. Finally, we identified current challenges and further provided some suggestions to improve the implementation of CRC screening programs. To maximize the effectiveness of CRC screening, further research on risk prediction models including polygenic risk scores and prior screening outcomes, novel biomarkers and artificial intelligence, and personalized screening strategies are recommended. Both cohort study and microsimulation techniques are recommended for long-term evaluations of the effectiveness of CRC screening strategies.