Abstract
BACKGROUND: Implementing Enhanced Recovery After Surgery (ERAS) guidelines has been demonstrated to reduce complications; however, it is unknown if ERAS may influence incidence of postoperative venous thromboembolism, a particularly challenging complication. The objective of this study was to examine the association between ERAS compliance and venous thromboembolism across multiple surgery types. METHODS: This retrospective cohort study included adult patients undergoing one of seven ERAS-guided surgeries between 2017 and 2021 at nine hospitals in Alberta, Canada, that implemented ERAS guidelines. The exposure was overall ERAS compliance (categorized as low, moderate, high) and compliance with each ERAS element. The primary outcome was venous thromboembolism within 30 days of surgery. Secondary outcomes included 30-day hospital readmission, emergency department visits and healthcare costs. RESULTS: Of the 8118 included patients, most had colorectal (52.8%) and gynaecologic (26.1%) surgery. There were 118 (1.5%) patients who experienced a postoperative venous thromboembolism. ERAS compliance was associated with developing a venous thromboembolism; each unit increase in the ERAS compliance score was associated with a 23% decrease in the occurrence of venous thromboembolism. More patients with venous thromboembolism had low (11.0%) or moderate (44.1%) overall ERAS compliance compared with those with no venous thromboembolism (5.6% and 34.5% respectively, P = 0.001). Using logistic regression analysis, the overall ERAS compliance score and American Society of Anesthesiologists class remained significant risk factors for developing a venous thromboembolism. CONCLUSIONS: ERAS compliance was associated with decreased odds of postoperative venous thromboembolism across multiple surgical disciplines, highlighting the importance of improving ERAS compliance to decrease postoperative venous thromboembolism.