Abstract
OBJECTIVE: To determine whether there is racial/ethnical discrepancy between pulse oximetry (SpO(2)) and oxygen saturation (SaO(2)) in patients receiving extracorporeal membrane oxygenation (ECMO). METHODS: This was a retrospective observational study at a tertiary academic ECMO center with adults (>18 years) on venoarterial (VA) or venovenous (VV) ECMO. Datapoints were excluded if oxygen saturation ≤70% or SpO(2)-SaO(2) pairs were not measured within 10 minutes. The primary outcome was the presence of a SpO(2)-SaO(2) discrepancy between different races/ethnicities. Bland-Altman analyses and linear mixed-effects modeling, adjusting for prespecified covariates, were used to assess the SpO(2)-SaO(2) discrepancy between races/ethnicities. Occult hypoxemia was defined as SaO(2) <88% with a time-matched SpO(2) ≥92%. RESULTS: Of 139 patients receiving VA-ECMO and 57 patients receiving VV-ECMO, we examined 16,252 SpO(2)-SaO(2) pairs. The SpO(2)-SaO(2) discrepancy was greater in VV-ECMO (1.4%) versus VA-ECMO (0.15%). In VA-ECMO, SpO(2) overestimated SaO(2) in Asian (0.2%), Black (0.94%), and Hispanic (0.03%) patients and underestimated SaO(2) in White (-0.06%) and nonspecified race (-0.80%) patients. The proportion of SpO(2)-SaO(2) measurements considered occult hypoxemia was 70% from Black compared to 27% from White patients (P < .0001). In VV-ECMO, SpO(2) overestimated SaO(2) in Asian (1.0%), Black (2.9%), Hispanic (1.1%), and White (0.50%) patients and underestimated SaO(2) in nonspecified race patients (-0.53%). In linear mixed-effects modeling, SpO(2) overestimated SaO(2) by 0.19% in Black patients (95% confidence interval, 0.045%-0.33%, P = .023). The proportion of SpO(2)-SaO(2) measurements considered occult hypoxemia was 66% from Black compared with 16% from White patients (P < .0001). CONCLUSIONS: SpO(2) overestimates SaO(2) in Asian, Black, and Hispanic versus White patients, and this discrepancy was greater in VV-ECMO versus VA-ECMO, suggesting the need for physiological studies.