Abstract
This paper makes the case for expanding the field of global mental health to give more attention to the social determinants of mental health. It does so by describing challenges and opportunities for intervening to address these social determinants, and by presenting some potential approaches to the choice, design and evaluation of such interventions, especially in low and middle-income countries. Challenges include distal interventions, limits to the modifiability of some social and economic determinants, poorly understood mechanisms, difficulty defining the boundaries of such interventions, the need for inter-disciplinary and inter-sectoral collaboration, limited datasets in LMIC, sample size challenges for prevention interventions, ethical issues and siloed research funding. Potential approaches include the development of more robust causal models, trial designs that allow for analysis of mechanisms and the pooling of data across diverse settings to explore the role of contextual variables. Several criteria can inform the selection of interventions that target social determinants and these include the need for plausible mechanisms, feasibility, acceptability, cultural validity of moderator, mediator and outcome variables, generalizability and sustainability. These approaches require a high level of inter-sectoral and inter-disciplinary cooperation and data sharing across sites internationally. Examples are provided from ongoing research in LMIC.