Combining experiment and prediction to explore surface chemistry and dissolution

A crystal structure is often an integral component in the development of a new pharmaceutical product, and these structures are frequently used to understand, assess and often predict both the manufacturing and in vivo behaviour of these compounds. Combining a range of analytical methods with computational analysis of the crystal surfaces, Zmeškalová et al. [(2025). IUCrJ, 12, 141-154] link the properties of three solid forms of a biologically active molecule to its dissolution behaviour.