Abstract
BACKGROUND: Scars are a common outcome of wound healing, affecting millions worldwide. These marks can result from various causes. However, current treatments, such as dermal fillers and laser therapy, often have limitations, including transient effects that do not stimulate the body's natural regenerative processes, high costs, and potential adverse reactions. OBJECTIVES: The objective of this study is to explore the potential therapeutic synergistic effect of a novel combination therapy using agarose and autologous platelet-rich plasma (PRP) to improve the appearance and characteristics of acne, atrophic, and hypertrophic scars. METHODS: This retrospective case series included 8 patients with acne, atrophic, and hypertrophic scars. All participants received a 50/50% mixture of agarose 1% and autologous PRP injected into the affected areas. Acne scars were evaluated using the Goodman and Baron Qualitative Acne Scar Grading System and the Investigator Global Acne Scarring (IGAS) scale. Atrophic and hypertrophic scars were assessed using the Modified Scar Assessment Scale (MSAS) and Investigator Global Aesthetic Improvement Scale (IGAIS). Patient satisfaction for all scar types was measured using the Patient Satisfaction Scale (PSS) at the final follow-up. RESULTS: Combined agarose-PRP therapy demonstrated clinical improvement in all treated scars. Acne scar patients (n = 2) showed a mean improvement of 2 points on the Goodman and Baron scale and the IGAS. For atrophic scar patients (n = 6), the MSAS scores improved from Grade 3-4 to Grade 0-1. IGAIS scores ranged from +2 to +3. PSS was high, with most patients reporting being "very satisfied" or "moderately satisfied." Representative images show visible improvements in scar depth, texture, and overall appearance. CONCLUSIONS: Agarose-PRP filler shows promise for scar treatment. Physicians should be aware that these findings may represent an effective treatment option for patients. These results may be helpful in guiding treatment decisions for scar management.