Abstract
BACKGROUND: Sepsis remains a major health condition with a high mortality rate that may be related to immunosuppression. T lymphocyte subsets may reflect the immune function of sepsis patients. The purpose of this study was to investigate the predictive value of CD4(+) T lymphocyte counts of ICU patients for their short-term prognosis. METHODS: We conducted a prospective, observational cohort study in a general ICU and enrolled patients with sepsis using the Sepsis-3 criteria. Peripheral blood samples were collected within 24 hours of enrollment or measurement of blood cell analysis and biomarkers of CD4(+) T lymphocytes and CD8(+) T lymphocytes. Severity was classified by the Acute Physiology and Chronic Health Evaluation II and Sequential Organ Failure Assessment (SOFA) scores. The primary outcome was 28-day mortality. RESULTS: A total of 100 patients with sepsis were enrolled and analyzed. CD4(+) T lymphocyte counts gradually decreased based on 28-day mortality (p < 0.001). Similarly, multivariate logistic regression analysis showed that only CD4(+) T lymphocyte counts were an independent predictor of 28-day mortality in sepsis patients. The area under the receiver operating characteristic curve of the combination of CD4(+) T lymphocyte counts and the SOFA score was 0.78. CONCLUSION: Our study demonstrated that CD4(+) T lymphocyte counts are associated with 28-day mortality. A combination of CD4(+) T lymphocyte counts with the SOFA score increased the predictive accuracy for 28-day mortality.