Abstract
Low-extremity peripheral artery disease (LE-PAD) is often associated with coronary artery disease (CAD). Development of biomarkers is needed to identify those among LE-PAD patients who have associated CAD. The pharmacologic profile of adenosine A(2A) receptors (A(2A)R; expression, cyclic adenosine monophosphate [cAMP] production, half maximal effective concentration [EC(50)]) evaluated on peripheral blood mononuclear cells is useful because these parameters are modified during myocardial ischemia. A total of 127 patients were included; 75 with CAD had a positive flow-fraction-reserve (FFR) but no intermittent claudication. Among those with LE-PAD, 27 had a positive FFR, and 25 had a negative FFR. The A(2A)R expression and EC(50) were lower in patients with a positive FFR vs a negative FFR. Obstructive CAD might be detected by measuring the adenosine A(2A)R profile.