Abstract
BACKGROUND: Pregnancy-induced hypertension (PIH) poses a significant threat to maternal health. This study aims to explore the association between PIH and the risk of atherosclerotic cardiovascular disease (ASCVD). METHODS: The cohort comprised 1947 pregnant women delivering a single child between 2004 and 2020 in the Kailuan study. Participants, categorized into PIH and non-PIH (NPIH) groups based on PIH history, completed questionnaires and underwent physical examinations and laboratory assessments within 2 years after delivery. Predicted ASCVD risks used the Atherosclerotic Cardiovascular Disease Risk in China (China-PAR) model, distinguishing lifetime ASCVD risk as "low" (<32.8%) and "high" (≥32.8%). χ(2) tests and logistic regression were used to investigate the association between PIH and high lifetime risk China-PAR categories. RESULTS: Overall, 6.17% of the PIH group had high lifetime risk, compared with 0.96% in the NPIH group (χ(2) 29.59, P < 0.001). After adjusting for confounders, PIH was independently associated with high-risk China-PAR categories, with the PIH group having a 5.03 times higher probability than the NPIH group (95% CI 2.20-11.51, P < 0.01). CONCLUSION: Pregnancy-induced hypertension was associated with increased lifetime risk of ASCVD.