Common variant in myocilin gene is associated with high myopia in isolated population of Korcula Island, Croatia

克罗地亚科尔丘拉岛一个与世隔绝的人群中,肌纤蛋白基因的常见变异与高度近视有关。

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Abstract

AIM: To study the association between genetic variants in myocilin and collagen type I alpha 1 genes and high myopia in an isolated island population. METHODS: A total of 944 examinees from the genetic epidemiology study conducted on the island of Korcula, Croatia, were included in the study. We selected 2 short nucleotide polymorphisms (SNP) available in our genome-wide scan set of SNPs that were previously associated with high myopia and used them to replicate previous claims of possible association. RESULTS: Nineteen cases of high myopia, defined as the refraction of

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