Abstract
Amyloidosis is a disorder caused by extracellular deposition of insoluble protein fibrils in various tissues. Colonic amyloidosis is a rare clinical manifestation which can mimic tumor, inflammatory bowel disease, or ischemic colitis. The most common symptoms of colonic amyloidosis include bleeding, ulceration, diarrhea, and abdominal pain. However, colonic obstruction due to extensive submucosal amyloidosis is extremely rare. Considering the wide variety of symptoms and potentially effected organs, the diagnosis can be challenging particularly in emergent conditions. In this paper, a case with mechanic bowel obstruction due to extensive amyloidotic involvement of the left colon is presented.