Abstract
BACKGROUND: Carcinoma of breast is a leading cause of death in women throughout the world. Difficulty in diagnosis occurs in routine Hematoxylin and Eosin (H&E) stained sections to differentiate premalignant lesions like epitheliosis and malignant lesions like carcinoma in situ which may affect prognosis. AIMS: Our study was done to assess the role of proliferative markers in this field. MATERIALS AND METHODS: In this study, total 66 cases of different breast lesions were studied by H&E stained sections as well as proliferative markers like silver staining nucleolar organizer region (AgNOR) and proliferating cell nuclear antigen (PCNA). RESULTS: Statistically significant differences found in expression of proliferative markers between most of them. CONCLUSION: Study of proliferative markers help in the proper diagnosis of different breast lesions which lies in the grey zone on routine histopathology.