Discussion
Inflammatory processes may play a significant role in the cycles of pain and sleep disturbance. Clinical interventions that improve sleep and reduce concomitant inflammatory dysregulation hold promise for chronic pain management.
Methods
Sex-matched and age-matched adults with chronic low back pain (CLBP; n=25) or without chronic pain (controls; n=25)completed measures of sleep quality in the past month and depressive symptoms in the past week, and provided a blood sample for IL-6. The next morning, participants reported their sleep quality the previous night and their current experience of morning pain.
Results
Individuals with CLBP had more sleep disturbance than controls. Circulating IL-6 levels were similar for the 2 groups; however, in adults with CLBP, poorer sleep quality was associated with higher IL-6 levels, and both sleep and IL-6 related to pain reports. Unlike CLBP participants, controls showed normal, age-related increases in IL-6 levels, whereas sleep quality was unrelated to IL-6 levels. Depressive symptoms could not fully explain the observed associations.