Abstract
Microfluidic systems enhance photocatalytic efficiency through superior mass/energy transfer and precise parameter control. Here, an electron-mediator-free microfluidic platform is designed for photocatalytic coenzyme NAD(P)H regeneration by integrating ultrathin BiOBr nanosheets. This architecture enables direct electron-proton coupling, achieving 100% NAD(+) conversion within 126 s with exceptional selectivity (72.30%) for bioactive 1,4-NADH. Continuous operation over 32 h shows no activity decay, demonstrating unparalleled stability. This study establishes a benchmark for designing integrated photocatalytic systems and highlights their broad potential for applications in biocatalysis, synthetic biology, and renewable energy.