Abstract
Chronic invasive fungal rhinosinusitis (CIFRS) is a rare disease caused by fungal infection and has an insidious course, which generally presents with headache at first, resulting in misdiagnosis and underestimation. Migraine is the most common primary headache and has symptoms mimicking rhinosinusitis. As a result, this may contribute to confusion of diagnosis when we consider the reason of headache, especially in patients suffering from migraine and rhinosinusitis at the same time. Here, we report a patient diagnosed with CIFRS and chronic migraine with the help of next-generation sequencing examination, to provide a reference in clinical treatment.