Abstract
Infective endocarditis (IE) is a life-threatening infection, which has had a notable increase in incidence in recent years. Although Staphylococci or Streptococci are the most common culprit organisms, rarer organisms have also been implicated and associated with a more aggressive disease course. We present a case of Enterobacter cloacae IE affecting the aortic valve in an 82-year-old male with an implantable permanent pacemaker. Our case demonstrates that a prolonged-course of beta-lactam therapy may be an effective, non-invasive management option for IE caused by multidrug-resistant gram-negative organisms.