Abstract
We present the case of an 18-year-old male with bilateral idiopathic chorioretinitis maintained on immunosuppressive therapy with prednisone, adalimumab, and mycophenolate mofetil, who developed ulcers and bleeding of the lip mucosa after taking nonsteroidal anti-inflammatory drugs (NSAIDs) and amoxicillin/clavulanate for a suspected ear infection. The clinical presentation initially mimicked Stevens-Johnson syndrome (SJS), but further evaluation confirmed the diagnosis of herpetic gingivostomatitis. This case highlights the diagnostic challenges in differentiating between drug eruptions and infectious etiologies in immunosuppressed patients. Despite its severity, prompt recognition and antiviral therapy can lead to full recovery.