Abstract
The current SARS-CoV-2 pandemic gave rise to a spirit of methodological anarchy in some fronts of biomedical research, embraced by some under the excuses of urgency and time restraints. This movement, however, comes at the same time when social sciences begin to recognize the value and soundness of the clinical research rationale - the need for randomization, of fair comparisons between intervention groups, the humility of acknowledging ignorance and accepting uncertainty, these last two imperatives usually subsumed under the principle of "equipoise".