Abstract
Ca(2+), as critical second messengers in biological processes, plays a pivotal role in the regulation of diverse cellular signaling pathways. The dysregulation of calcium signaling is intricately linked to the progression of various cancers. The capacity of Ca(2+) to modulate cell death and proliferation, along with its potential for pharmacological manipulation, presents a promising avenue for the development of novel cancer therapeutics. This review provides a comprehensive overview of the classification of Ca(2+) channels and their mechanisms of action in oncogenesis, explores the application of Ca(2+) blockers in cancer treatment, and underscores the importance of conducting further clinical trials.